Research

Science based.
Heart led.

Mitokatlyst™, the key ingredient in our first product, Mitokatlyst™-E, is the only clinically tested molecule known to stimulate mitochondrial biogenesis, support ATP production, protect mitochondria from damage and dysfunction, and support optimal mitophagy.*

Structural requirements for Mitokatlyst™ activity are highly specific. Closely related structural analogs not only have no efficacy but can also antagonize the effect of this molecule. The product has an exceptional Safety Profile and works at a precise dose and purity.

Scientific Publications

Dr. Sundeep Dugar – PubMed

Our Core Research

Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (−)-epicatechin in healthy volunteers.* READ MORE

Effects of (−)-epicatechin on molecular modulators of skeletal muscle growth and differentiation.* READ MORE

(−)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy.*
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Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects.*
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(−)-Epicatechin Activation of Endothelial Cell Endothelial Nitric Oxide Synthase, Nitric Oxide, and Related Signaling Pathways.* READ MORE

A randomized, placebo-controlled, double-blind study on the effects of (−)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects.*
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Improving Cardiovascular Risk in Postmenopausal Women with an (-)-Epicatechin-Based Nutraceutical: A Randomly Assigned, Double-Blind vs. Placebo, Proof-of-Concept Trial*
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Perturbations in skeletal muscle sarcomere structure in patients with heart failure and Type 2 diabetes: restorative effects of (−)-epicatechin-rich cocoa * READ MORE

(-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients * READ MORE

Other Select Research

(−)-Epicatechin Activation of Endothelial Cell Endothelial Nitric Oxide Synthase, Nitric Oxide, and Related Signaling Pathways*
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11-β-hydroxysterols as possible endogenous stimulators of mitochondrial biogenesis as inferred from epicatechin molecular mimicry* READ PAPER

New Trends to Treat Muscular Atrophy: A Systematic Review of Epicatechin* READ PAPER

In Progress & Upcoming Clinical Trials & Observational Studies

Chronic Kidney Disease (CKD) Human clinical trial to evaluate the effect of (-)-Epicatechin (Blue Oak Nutraceuticals inc. Mitokatlyst™ – E) on mitochondrial dysfunction, muscle function, muscle mass, and myosteatosis in Chronic Kidney Disease (CKD). Initiated at Karolinska Institutet, Sweden. ClinicalTrials.gov ID – NCT06631820
Biomarkers in Mitochondrial Disease Clinical Trial – U.S. University
Primary Mitochondrial Disease Clinical Trial – U.S. University
Frontal Lobe Dementia (FLD) Clinical Trial – U.S. University
Mitochondrial Disease Observational Study – U.S. University
Spinal Muscular Atrophy (SMA) Observational Study – U.S. University
Inclusion Body Myositis (IBM) Observational Study – U.S. University
Necrotic Kidney Disease Observational Study – U.S. University
Mental Health Observational Study – U.S. University